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Mouse Monoclonal Antibody to ADRB2

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to ADRB2 AO2464a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - Mouse Monoclonal Antibody to ADRB2 AO2464a
    Western blot analysis using ADRB2 mAb against human ADRB2 (AA: 302-413) recombinant protein. (Expected MW is 38.5 kDa)
    detail
  • WB - Mouse Monoclonal Antibody to ADRB2 AO2464a
    Western blot analysis using ADRB2 mAb against HEK293 (1) and ADRB2 (AA: 302-413)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • WB - Mouse Monoclonal Antibody to ADRB2 AO2464a
    Western blot analysis using ADRB2 mouse mAb against C6 (1) cell lysate.
    detail
  • FC - Mouse Monoclonal Antibody to ADRB2 AO2464a
    Flow cytometric analysis of MCF-7 cells using ADRB2 mouse mAb (green) and negative control (red).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P07550
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Clone Names 5G3B5
Isotype Mouse IgG1
Calculated MW 46.5kDa
Description This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.;
Immunogen Purified recombinant fragment of human ADRB2 (AA: 302-413) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 154
Other Names BAR; B2AR; ADRBR; ADRB2R; BETA2AR
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to ADRB2 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRB2
Synonyms ADRB2R, B2AR
Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine.
Cellular Location Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) Activated receptors are also detected within the Golgi apparatus (PubMed:27481942).
Research Areas
Citations (0)
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References

1.World J Gastroenterol. 2015 Jun 21;21(23):7191-6. ; 2.Adv Exp Med Biol. 2015;842:247-61.;

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$ 385.00
Cat# AO2464a
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