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> home > Products > Primary Antibodies > Antibody Collections > Viral process > Mouse Monoclonal Antibody to PLCG1
Mouse Monoclonal Antibody to PLCG1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P19174 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F3E10 |
| Isotype | Mouse IgG2a |
| Calculated MW | 148.5kDa |
| Description | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.; |
| Immunogen | Purified recombinant fragment of human PLCG1 (AA: 39-181) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
| Gene ID | 5335 |
|---|---|
| Other Names | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to PLCG1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLCG1 (HGNC:9065) |
|---|---|
| Synonyms | PLC1 |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). |
| Cellular Location | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Cancer Discov. 2014 Apr;4(4):OF13. ; 2.Adv Biol Regul. 2013 Jan;53(1):51-62.;
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$ 385.00
Cat# AO2452a
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