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Mouse Monoclonal Antibody to IL1R1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P14778 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4D2D12 |
| Isotype | Mouse IgG1 |
| Calculated MW | 65.4kDa |
| Description | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.; |
| Immunogen | Purified recombinant fragment of human IL1R1 (AA: 18-167) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
| Gene ID | 3554 |
|---|---|
| Other Names | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to IL1R1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL1R1 |
|---|---|
| Synonyms | IL1R, IL1RA, IL1RT1 |
| Function | Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa- B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). |
| Cellular Location | Membrane; Single- pass type I membrane protein. Cell membrane. Secreted |
| Tissue Location | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2015 Jun 22;10(6):e0131086. ; 2.Biochem Pharmacol. 2011 Nov 1;82(9):1153-62.;
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$ 385.00
Cat# AO2439a
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