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Mouse Monoclonal Antibody to SUZ12

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to SUZ12 AO2380a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - Mouse Monoclonal Antibody to SUZ12 AO2380a
    Western blot analysis using SUZ12 mAb against human SUZ12 (AA: 1-139) recombinant protein. (Expected MW is 39.9 kDa)
    detail
  • WB - Mouse Monoclonal Antibody to SUZ12 AO2380a
    Western blot analysis using SUZ12 mAb against HEK293 (1) and SUZ12 (AA: 1-139)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • FC - Mouse Monoclonal Antibody to SUZ12 AO2380a
    Flow cytometric analysis of Hela cells using SUZ12 mouse mAb (green) and negative control (red).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q15022
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2B9G12
Isotype Mouse IgG1
Calculated MW 83kDa
Description This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.;
Immunogen Purified recombinant fragment of human SUZ12 (AA: 1-139) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 23512
Other Names CHET9; JJAZ1
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to SUZ12 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUZ12
Synonyms CHET9, JJAZ1, KIAA0160
Function Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Cellular Location Nucleus Note=Localizes to chromatin as part of the PRC2 complex
Tissue Location Overexpressed in breast and colon cancer.
Research Areas
Citations (0)
citation

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References

1.Tumour Biol. 2014 Jun;35(6):6073-82. ; 2.Cell Physiol Biochem. 2013;31(6):778-84.;

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$ 385.00
Cat# AO2380a
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