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Mouse Monoclonal Antibody to LMNB2
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | Q03252 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2E2F4 |
| Isotype | Mouse IgG2b |
| Calculated MW | 67.7kDa |
| Description | This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.; |
| Immunogen | Purified recombinant fragment of human LMNB2 (AA: 401-600) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 ICC: 1/200 - 1/1000 FCM: 1/200 - 1/400 |
| Gene ID | 84823 |
|---|---|
| Other Names | LMN2; LAMB2 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to LMNB2 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LMNB2 |
|---|---|
| Synonyms | LMN2 |
| Function | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). |
| Cellular Location | Nucleus lamina. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Pediatr Endocrinol Metab. 2012;25(3-4):375-7. ; 2.FEBS Lett. 2006 Nov 13;580(26):6211-6. ;
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$ 385.00
Cat# AO2338a
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