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Mouse Monoclonal Antibody to UCP3
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | P55916 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6B8C6 |
| Isotype | Mouse IgG2a |
| Calculated MW | 34.2kDa |
| Description | Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.; |
| Immunogen | Purified recombinant fragment of human UCP3 (AA: 1-113 and 217-312) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 ICC: 1/200 - 1/1000 |
| Gene ID | 7352 |
|---|---|
| Other Names | SLC25A9 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to UCP3 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UCP3 {ECO:0000303|PubMed:9180264, ECO:0000312|HGNC:HGNC:12519} |
|---|---|
| Function | Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:11171965, PubMed:12670931, PubMed:12734183, PubMed:9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P56501}; Multi-pass membrane protein |
| Tissue Location | Only in skeletal muscle and heart (PubMed:9305858). Also expressed in white and brown adipose tissues (PubMed:9305858). Is more expressed in glycolytic than in oxidative skeletal muscles |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Biol Chem. 2011 Sep 16;286(37):32533-41. ; 2.Nutr Hosp. 2012 Jul-Aug;27(4):1190-5. ;
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$ 385.00
Cat# AO2337a
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