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> home > Products > Primary Antibodies > Antibody Collections > Viral process > Mouse Monoclonal Antibody to YWHAB
Mouse Monoclonal Antibody to YWHAB
Purified Mouse Monoclonal Antibody
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Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | P31946 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5B5G10 |
| Isotype | Mouse IgG2b |
| Calculated MW | 28kDa |
| Description | This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.; |
| Immunogen | Purified recombinant fragment of human YWHAB (AA: 1-246) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 ICC: 1/200 - 1/1000 FCM: 1/200 - 1/400 |
| Gene ID | 7529 |
|---|---|
| Other Names | HS1; GW128; YWHAA; KCIP-1; HEL-S-1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to YWHAB is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | YWHAB |
|---|---|
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Cellular Location | Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.BMC Res Notes. 2014 Feb 20;7:97. ; 2.Mol Biol Rep. 2012 Dec;39(12):10647-53.;
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$ 385.00
Cat# AO2325a
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