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PAX3 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23760 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7D8G7 |
| Isotype | IgG1 |
| Calculated MW | 53kDa |
| Description | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. |
| Immunogen | Purified recombinant fragment of human PAX3 (AA: 142-203) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 5077 |
|---|---|
| Other Names | Paired box protein Pax-3, HuP2, PAX3, HUP2 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX3 |
|---|---|
| Synonyms | HUP2 |
| Function | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Cell Death Differ. 2012 Apr;19(4):616-22. 2. Biochem Biophys Res Commun. 2011 Aug 12;411(4):832-7.
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