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PDE1B Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q01064 |
| Reactivity | Human, Mouse, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10B10B12 |
| Isotype | IgG1 |
| Calculated MW | 61.4kDa |
| Description | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Immunogen | Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 5153 |
|---|---|
| Other Names | Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 3.1.4.17, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE1B (HGNC:8775) |
|---|---|
| Synonyms | PDES1B |
| Function | Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816). |
| Cellular Location | Cytoplasm, cytosol. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Biol Chem. 2007 Nov 9;282(45):32749-57. 2.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):497-502.
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$ 385.00
Cat# AO2283a
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