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> home > Products > Primary Antibodies > Antibody Collections > Anti-Wnt-Pathway (plus Lgr5) Antibodies > BMPR1A Antibody
BMPR1A Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | P36894 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B7B2 |
| Isotype | IgG1 |
| Calculated MW | 60kDa |
| Description | The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. |
| Immunogen | Purified recombinant fragment of human BMPR1A (AA: 179-378 ) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 657 |
|---|---|
| Other Names | Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, 2.7.11.30, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BMPR1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BMPR1A |
|---|---|
| Synonyms | ACVRLK3, ALK3 |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein. Cell surface {ECO:0000250|UniProtKB:P36895} |
| Tissue Location | Highly expressed in skeletal muscle. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):551-5. 2.Gastroenterology. 2011 Jul;141(1):e23-6.
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$ 385.00
Cat# AO2246a
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