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HIST2H4A(20Me) Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, ICC, E |
|---|---|
| Primary Accession | P62805 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3E7D9 |
| Isotype | IgG1 |
| Calculated MW | 11.4kDa |
| Description | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. |
| Immunogen | Synthesized peptide of human HIST2H4A ( AA: GGAKRHRK(Me)VLRDNIQ ) . |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 121504;554313;8294;8359;8360;8361;8362;8363;8364;8365;8366;8367;8368;8370 |
|---|---|
| Dilution | E~~1/10000 IF~~1/200 - 1/1000 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIST2H4A(20Me) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | H4C1 |
|---|---|
| Synonyms | H4/A, H4FA, HIST1H4A |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Cellular Location | Nucleus. Chromosome. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Virol. 2011 Dec;85(24):13234-52.2.Mol Cell Biol. 2003 Feb;23(4):1460-9.
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$ 385.00
Cat# AO2144a
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