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CBX4 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, E |
|---|---|
| Primary Accession | O00257 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6C5G3 |
| Isotype | IgG1 |
| Calculated MW | 61.4kDa |
| Description | CBX4 (chromobox homolog 4) is a protein-coding gene. Diseases associated with CBX4 include brain cancer. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CBX8. |
| Immunogen | Purified recombinant fragment of human CBX4 (AA: 397-514) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 8535 |
|---|---|
| Other Names | E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX4 |
|---|---|
| Function | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). |
| Cellular Location | Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235) |
| Tissue Location | Ubiquitous. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Cell Stem Cell. 2011 Sep 2;9(3):233-46.2.Ann Surg Oncol. 2013 Dec;20 Suppl 3:S684-92.
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$ 385.00
Cat# AO2074a
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