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LDLR Antibody

Purified Mouse Monoclonal Antibody

     
  • E - LDLR Antibody AO2034a

    Figure 1:Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

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  • WB - LDLR Antibody AO2034a

    Figure 2:Western blot analysis using LDLR mAb against human LDLR (AA: 22-150) recombinant protein. (Expected MW is 22-150 kDa)

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  • WB - LDLR Antibody AO2034a

    Figure 3:Western blot analysis using LDLR mAb against HEK293 (1) and LDLR(AA: 22-150)-hIgGFc transfected HEK293 (2) cell lysate.

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  • FC - LDLR Antibody AO2034a

    Figure 4:Flow cytometric analysis of *** cells using *** mouse mAb (green) and negative control (red).

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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P01130
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7H5B11
Isotype IgG1
Calculated MW 95.4kDa
Description The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Immunogen Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3949
Other Names Low-density lipoprotein receptor, LDL receptor, LDLR
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLDLR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LDLR
Function Binds low density lipoprotein /LDL, the major cholesterol- carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021).
Cellular Location Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01131}. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome Note=Rapidly endocytosed upon ligand binding. Localized at cell membrane, probably in lipid rafts, in serum-starved conditions (PubMed:30443021).
Research Areas
Citations (0)
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References

Phytother Res. 2012 Nov;26(11):1688-94.Biochim Biophys Acta. 2011 Jun;1811(6):397-408.

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$ 385.00
Cat# AO2034a
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