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RANGAP1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P46060 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4F9E2 |
| Isotype | IgG1 |
| Calculated MW | 63.5kDa |
| Description | This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. |
| Immunogen | Purified recombinant fragment of human RANGAP1 (AA: 359-587) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
| Gene ID | 5905 |
|---|---|
| Other Names | Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RANGAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RANGAP1 |
|---|---|
| Synonyms | KIAA1835, SD |
| Function | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). |
| Cellular Location | Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). |
| Tissue Location | Highly expressed in brain, thymus and testis. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells ; ;
References
1. J Cell Biol. 2012 Feb 20;196(4):435-50. 2. Cancer Res. 2011 Jul 15;71(14):4968-76.
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$ 385.00
Cat# AO1960a
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