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GAB1 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - GAB1 Antibody AO1708a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

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  • WB - GAB1 Antibody AO1708a
    Figure 1: Western blot analysis using GAB1 mAb against human GAB1 (AA: 661-724) recombinant protein. (Expected MW is 32.4 kDa)
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  • WB - GAB1 Antibody AO1708a
    Figure 2: Western blot analysis using GAB1 mouse mAb against HEK293 (1) cell lysate.
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  • IHC - GAB1 Antibody AO1708a
    Figure 3: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using GAB1 mouse mAb with DAB staining.
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  • IHC - GAB1 Antibody AO1708a
    Figure 4: Immunohistochemical analysis of paraffin-embedded kidney tissues using GAB1 mouse mAb with DAB staining.
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  • FC - GAB1 Antibody AO1708a
    Figure 5: Flow cytometric analysis of Jurkat cells using GAB1 mouse mAb (green) and negative control (red).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC, E
Primary Accession Q13480
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A7
Isotype IgG1
Calculated MW 76.6kDa
Description The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Purified recombinant fragment of human GAB1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2549
Other Names GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGAB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAB1
Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Research Areas
Citations (0)
citation

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References

Cell Signal. 2009 Dec;21(12):1775-83. Cell. 2009 Jan 23;136(2):352-63.

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$ 385.00
Cat# AO1708a
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