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> home > Products > Primary Antibodies > Antibody Collections > MHC class l-like antigen recognition > HFE Antibody
HFE Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | Q30201 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3F1 |
| Isotype | IgG1 |
| Calculated MW | 40kDa |
| Description | The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. |
| Immunogen | Purified recombinant fragment of human HFE expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 3077 |
|---|---|
| Other Names | Hereditary hemochromatosis protein, HLA-H, HFE, HLAH |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HFE Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HFE |
|---|---|
| Synonyms | HLAH |
| Function | Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in all tissues tested except brain. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Respir Med. 2009 Dec;103(12):1866-70. 2. Clin J Am Soc Nephrol. 2009 Aug;4(8):1331-7.
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$ 385.00
Cat# AO1622a
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