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STAT5B Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - STAT5B Antibody AO1427a
    Figure 1: Western blot analysis using STAT5B mouse mAb against Hela (1), K562 (2), NIH/3T3 (3), C6 (4), HEK293 (5), Jurkat (6) and HL-60 (7) cell lysate.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P51692
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5B3
Isotype IgG1
Calculated MW 90kDa
Description The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Immunogen Purified recombinant fragment of human STAT5B expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Additional Information
Gene ID 6777
Other Names Signal transducer and activator of transcription 5B, STAT5B
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTAT5B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT5B
Function Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Research Areas
Citations (0)
citation

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References

1. Mol Cancer. 2009 Aug 26;8:67. 2. Bone. 2010 Feb;46(2):524-33.

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$ 325.00
Cat# AO1427a
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