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ETS1 Antibody
Mouse Monoclonal Antibody to ETS1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P14921 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10D2 |
| Isotype | Mouse IgG1 |
| Calculated MW | 50408 Da |
| Description | The ETS1 is a transcription factor known to regulate expression of a number of genes involved in extracellular matrix remodeling. ETS1 is absent from normal gastric epithelium but is expressed in approximately 60% of gastric carcinomas and oral squamous cell carcinomas with a significant correlation to the tumor stage. |
| Immunogen | Purified recombinant fragment of human ETS1 expressed in E. Coli. |
| Gene ID | 2113 |
|---|---|
| Other Names | Protein C-ets-1, p54, ETS1, EWSR2 |
| Target/Specificity | Purified recombinant fragment of human ETS1 expressed in E. Coli. |
| Dilution | WB~~1:500~~2000 IHC~~1:200~~1000 |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ETS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ETS1 |
|---|---|
| Synonyms | EWSR2 |
| Function | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). |
| Cellular Location | Nucleus. Cytoplasm Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
| Tissue Location | Highly expressed within lymphoid cells. Isoforms c- ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. DNA Cell Biol. 2005 Feb;24(2):126-32.
2. Mol Hum Reprod. 2006 Feb;12(2):71-6.
3. J Biol Chem. 2008 Jan 11;283(2):951-62.
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$ 325.00
Cat# AO1354b
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