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MPS1 Antibody
Mouse Monoclonal Antibody to MPS1
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Application 
| ICC, E |
|---|---|
| Primary Accession | P42677 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7000 |
| Isotype | Mouse IgG1 |
| Calculated MW | 9461 Da |
| Description | MPS1, also known as RPS27. It is a ribosomal protein. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. MPS1 is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. |
| Immunogen | Purified recombinant fragment of MPS1 expressed in E. Coli. |
| Gene ID | 6232 |
|---|---|
| Other Names | 40S ribosomal protein S27, Metallopan-stimulin 1, MPS-1, RPS27, MPS1 |
| Target/Specificity | Purified recombinant fragment of MPS1 expressed in E. Coli. |
| Dilution | ICC~~1:200~~1000 IF~~1:200~1000. |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPS27 (HGNC:10416) |
|---|---|
| Synonyms | MPS1 |
| Function | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). |
| Cellular Location | Cytoplasm. Nucleus, nucleolus |
| Tissue Location | Expressed in a wide variety of actively proliferating cells and tumor tissues. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47.
2. Mol Biol Cell. 2003 Apr;14(4):1638-51.
3. Cell. 2008 Jan 25;132(2):233-46.
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$ 325.00
Cat# AO1282b
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