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DKK1 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - DKK1 Antibody AO1266a
    Figure 1: Western blot analysis using DKK1 mouse mAb against HEK293 (1) and
    DKK1-hIgGFc transfected HEK293 cell lysate (2).
    detail
  • ICC - DKK1 Antibody AO1266a
    Figure 2: Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL mouse mAb(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
    detail
  • IF - DKK1 Antibody AO1266a
    Figure 2: Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using anti-AXL monoclonal antioby(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O94907
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H2
Isotype IgG2b
Calculated MW 28.7kDa
Description DKK1: dickkopf homolog 1 (Xenopus laevis), also known as SK. Entrez Protein NP_036374. DKK1 is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Immunogen Purified recombinant fragment of DKK1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 22943
Other Names Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Dilution WB~~1/500 - 1/2000
ICC~~1:200~~1000
IF~~1:200~1000.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDKK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKK1
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Cellular Location Secreted.
Tissue Location Placenta.
Research Areas
Citations (0)
citation

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References

1. Dev Cell. 2008 Jul;15(1):37-48. 2. Cancer Lett. 2008 Sep 28;269(1):67-77.

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$ 300.00
Cat# AO1266a
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