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Tyk2 Antibody
Purified Mouse Monoclonal Antibody
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P29597 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8G8B3; 8G8E9; 8G9H5 |
| Isotype | IgG1 |
| Calculated MW | 133650 Da |
| Description | Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance. |
| Immunogen | Purified recombinant fragment of Tyk2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 7297 |
|---|---|
| Other Names | Non-receptor tyrosine-protein kinase TYK2, 2.7.10.2, TYK2 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1:200~~1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Tyk2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TYK2 |
|---|---|
| Function | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). |
| Tissue Location | Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Michael H. Shaw, Gordon J. Freeman, Mark F. Scott. J. Immunol., Jun 2006; 176: 7263-7271. 2. Yohei Seto, Hiroshi Nakajima, Akira Suto. J. Immunol., Jan 2003; 170: 1077.
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$ 385.00
Cat# AO1072a
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