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TGF beta1 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - TGF beta1 Antibody AO1059a
    Figure 1: Western blot analysis using TGF beta1 mouse mAb against truncated TGF beta1 recombinant protein.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P01137
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4F9C10; 1B11B7
Isotype IgG2a
Calculated MW 44325 Da
Description TGF beta(transforming growth factor beta), with 390-amino acid protein (about 43 kDa), is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. In mammals, three isoforms of TGFbeta, that is, beta1, beta2,and beta3,are known. TGF beta is one of numerous inhibitory factors produced by cancer cells that regulate antitumor immunity. TGF beta1 takes part in the local response in the course of primary lung cancer and TGFbeta1 is thought to be implicated in breast cancer progression.TGFbeta1 also plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage.
Immunogen Purified recombinant fragment of TGF beta1 expressed in E. Coli.

Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7040
Other Names Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGF beta1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB1 (HGNC:11766)
Synonyms TGFB
Function Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Cellular Location [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix
Tissue Location Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158)
Research Areas
Citations (0)
citation

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References

1. Delphine Boche, Colm Cunningham, Fabian Docagne. Neurobiol Dis. 2006 Feb 27 2. Shizuya Saika. Lab Invest. 2006 Feb;86(2):106-15

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$ 300.00
Cat# AO1059a
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