Anti-PUMA Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BXH1 |
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Host | Rabbit |
Clonality | Rabbit Polyclonal |
Isotype | IgG |
Calculated MW | 20532 Da |
Gene ID | 27113 |
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Other Names | BBC3, Bcl-2-binding component 3, isoforms 1/2, JFY1, p53 up-regulated modulator of apoptosis |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Anti-PUMA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Shipping | Blue Ice |

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Provided below are standard protocols that you may find useful for product applications.
Background
A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

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