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Anti-Retinoic Acid Receptor, α-Isotype Antibody
Our Anti-Retinoic Acid Receptor, α-Isotype primary antibody from PhosphoSolutions is mouse monoclona
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10276 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 763 |
| Calculated MW | 50771 Da |
| Gene ID | 5914 |
|---|---|
| Other Names | NR1B1 antibody, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody, Nuclear receptor subfamily 1 group B member 1 antibody, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody, RAR alpha antibody, RAR antibody, RAR-alpha antibody, rara antibody, RARA_HUMAN antibody, RARalpha antibody, RARalpha1 antibody, Retinoic acid nuclear receptor alpha variant 1 antibody, Retinoic acid nuclear receptor alpha variant 2 antibody, Retinoic acid receptor alpha antibody, Retinoic acid receptor alpha polypeptide antibody |
| Target/Specificity | Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). |
| Format | Protein G Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Retinoic Acid Receptor, α-Isotype Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
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