Anti-Nicotinic Acetylcholine Receptor (nAChR) β2 Antibody
Our Anti-Nicotinic Acetylcholine Receptor (nAChR) β2 primary antibody from PhosphoSolutions is rabbi
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9ERK7 |
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Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 57113 Da |
Gene ID | 11444 |
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Other Names | Acetylcholine receptor beta 2 neural antibody, ACHB2_HUMAN antibody, ACHN antibody, AChR antibody, Acrb 2 antibody, Acrb2 antibody, b2 nAchR antibody, Cholinergic receptor nicotinic beta 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 neuronal antibody, cholinergic receptor nicotinic beta 2 (neuronal) antibody, Chrnb2 antibody, EFNL 3 antibody, EFNL3 antibody, nAChRB2 antibody, Neuronal acetylcholine receptor protein beta 2 chain precursor antibody, Neuronal acetylcholine receptor protein subunit beta 2 antibody, Neuronal acetylcholine receptor subunit beta-2 antibody, Neuronal nicotinic acetylcholine receptor beta 2 antibody |
Target/Specificity | Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits α4β2, whereas α3β4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, β2-containing receptors greatly outnumber receptors that contain β4 (McGehee & Role, 1995; Albuquerque, et al., 2009), and in most brain regions, targeted deletion of the β2 subunit virtually abolishes [3H]-epibatidine binding and receptor autoradiography (Zoli, et al., 1998) due to the absence of a β subunit required to form functional nAChRs (Champtiaux & Changeux, 2004). |
Format | Antigen Affinity Purified from Pooled Serum |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Anti-Nicotinic Acetylcholine Receptor (nAChR) β2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Shipping | Blue Ice |
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Background
Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits α4β2, whereas α3β4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, β2-containing receptors greatly outnumber receptors that contain β4 (McGehee & Role, 1995; Albuquerque, et al., 2009), and in most brain regions, targeted deletion of the β2 subunit virtually abolishes [3H]-epibatidine binding and receptor autoradiography (Zoli, et al., 1998) due to the absence of a β subunit required to form functional nAChRs (Champtiaux & Changeux, 2004).
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