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Anti-COBRA1 (NELF-B) Antibody
Our Anti-COBRA1 (NELF-B) primary antibody from PhosphoSolutions is mouse monoclonal. It detects huma
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WX92 |
|---|---|
| Reactivity | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | F7E4 |
| Calculated MW | 65697 Da |
| Gene ID | 25920 |
|---|---|
| Other Names | A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody |
| Target/Specificity | COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004) |
| Format | Protein G Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-COBRA1 (NELF-B) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)
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