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Tau Antibody

Chicken polyclonal antibody

     
  • WB - Tau Antibody AN1240
    Western blot of rat cortex lysate showing specific immunolabeling of the ~48, 65 & 75k tau isoforms.
    detail
  • IF - Tau Antibody AN1240
    Immunofluorescence of cultured rat hippocampal neurons showing staining of tau in red along the neuronal processes.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession P10636
Reactivity Human, Rat
Host Chicken
Clonality polyclonal
Calculated MW 78928 Da
Additional Information
Gene ID 4137
Gene Name MAPT
Other Names Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
Target/Specificity Recombinant full length human tau expressed in and purified from E.Coli.
Dilution WB~~ 1:10000
IF~~ 1:1000
Format Total IgY fraction
Antibody Specificity Specific for the ~48, 65 & 75k tau isoforms.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTau Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)
citation

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Background

Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy.

References

Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Bio Oct; 101(4):1371-8.
Goedert M. and Jakes R. (1990) Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9, 4225-4230.

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$ 310.00
Cat# AN1240
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Availability: 7-10 days
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