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Rhodopsin Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | P02699 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 |
| Clone Names | 1D4 |
| Calculated MW | 39 KDa |
| Gene ID | 509933 |
|---|---|
| Gene Name | RHO |
| Other Names | Rhodopsin, RHO |
| Target/Specificity | Purified native bovine rhodopsin. |
| Dilution | IHC~~ 1:100 |
| Format | Protein G purified culture supernatant. |
| Antibody Specificity | Specific for the ~ 39k rhodopsin protein. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Rhodopsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding.
References
Berson EL, Rosner B, Sandberg MA, Dryja TP
(1991). "Ocular findings in patients with
autosomal dominant retinitis pigmentosa and a rhodopsin gene defect (Pro-23-His)".
Arch.
Ophthalmol.
109
(1): 92–101.
Dryja TP, Berson EL, Rao VR, Oprian DD (1993) Heterozygous missense mutation in the
rhodopsin gene as a cause of congenital stationary night blindness. Nature Genet. 4:280-283.
Molday RS, MacKenzie D. (1983) Monoclonal ant
ibodies to rhodopsin: characterization, cross-
reactivity, and application as structural probes. Biochemistry. 22(3):653-60.
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