FDPS Antibody (Center)
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P14324 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | monoclonal |
Isotype | IgG2b,k |
Clone/Animal Names | 1049CT13.1.4 |
Calculated MW | 48275 Da |
Gene ID | 2224 |
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Other Names | Farnesyl pyrophosphate synthase, FPP synthase, FPS, 2.5.1.10, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, 2.5.1.1, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293 |
Target/Specificity | This FDPS antibody is generated from a mouse immunized with a recombinant protein of human FDPS. |
Dilution | WB~~1:2000-1:4000 |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FDPS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FDPS (HGNC:3631) |
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Synonyms | FPS, KIAA1293 |
Function | Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
Cellular Location | Cytoplasm. |
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Background
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
References
Wilkin D.J.,et al.J. Biol. Chem. 265:4607-4614(1990).
Nomura N.,et al.DNA Res. 1:27-35(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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