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TPM3 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P06753 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1649CT306.29.13 |
| Calculated MW | 32950 Da |
| Gene ID | 7170 |
|---|---|
| Other Names | Tropomyosin alpha-3 chain, Gamma-tropomyosin, Tropomyosin-3, Tropomyosin-5, hTM5, TPM3 |
| Target/Specificity | This TPM3 antibody is generated from a mouse immunized with a recombinant protein of human TPM3. |
| Dilution | WB~~1:2000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TPM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPM3 |
|---|---|
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Cellular Location | Cytoplasm, cytoskeleton. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
References
Reinach F.C.,et al.Nature 322:648-650(1986).
McLeod A.R.,et al.Nucleic Acids Res. 14:8413-8426(1986).
Clayton L.,et al.J. Mol. Biol. 201:507-515(1988).
Lin J.J.-C.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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