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RAB18 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9NP72 |
| Other Accession | Q5R5H5 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1573CT811.119.39 |
| Calculated MW | 22977 Da |
| Antigen Region | 1-206aa |
| Gene ID | 22931 |
|---|---|
| Other Names | Ras-related protein Rab-18, RAB18 |
| Target/Specificity | This RAB18 antibody is generated from a mouse immunized with a recombinant protein of human RAB18. |
| Dilution | WB~~1:500-1:2000 FC~~1:25 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB18 |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:P35293}. Lipid droplet. Endoplasmic reticulum membrane |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.
References
Chikri M.M.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Schaefer U.,et al.FEBS Lett. 466:148-154(2000).
Dou T.,et al.DNA Seq. 16:230-234(2005).
Cui W.C.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
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