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PPT1 Antibody (C-term)
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | P50897 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 1117CT11.2.1.4 |
| Calculated MW | 34193 Da |
| Antigen Region | 1-306 aa |
| Gene ID | 5538 |
|---|---|
| Other Names | Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1, PPT1, PPT |
| Target/Specificity | This PPT1 antibody is generated from a mouse immunized with a full-length recombinant protein from human PPT1. |
| Dilution | WB~~1:1000 IHC-P~~1:25 FC~~1:25 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPT1 |
|---|---|
| Synonyms | CLN1 {ECO:0000303|PubMed:19941651}, PPT |
| Function | Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). |
| Cellular Location | Lysosome. Secreted {ECO:0000250|UniProtKB:P45478} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
References
Vesa J.,et al.Nature 376:584-587(1995).
Crews C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:4316-4319(1996).
Schriner J.E.,et al.Genomics 34:317-322(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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