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PHB Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • WB - PHB Antibody AM2247b
    Western blot analysis of lysates from 293,MCF-7,HepG2,mouse NIH/3T3 cell line and rat liver tissue (from left to right),using USF1 Antibody (Center) (Cat. #AM2247b). AM2247b was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody.Lysates at 35μg per lane.
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  • IHC-P - PHB Antibody AM2247b
    Immunohistochemical analysis of paraffin-embedded H. stomach section using PHB Antibody(Cat#AM2247b). AM2247b was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession P35232
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone/Animal Names 1215CT487.109.106
Calculated MW 29804 Da
Antigen Region 1-205 aa
Additional Information
Gene ID 5245
Other Names Prohibitin, PHB
Target/Specificity This antibody is generated from a mice immunized with a recombinant protein between 1-205 amino acids from human.
Dilution WB~~1:1000
IHC-P~~1:25
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB1 {ECO:0000303|PubMed:28017329, ECO:0000312|HGNC:HGNC:8912}
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
Cellular Location Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane
Tissue Location Widely expressed in different tissues.
Research Areas
Citations (0)
citation

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Background

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

References

Sato T.,et al.Cancer Res. 52:1643-1646(1992).
Sato T.,et al.Genomics 17:762-764(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2005) to UniProtKB.
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 365.00
$ 140.00
Cat# AM2247b
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