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CTSD Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • WB - CTSD Antibody AM2221B
    Anti-CTSD Antibody at 1:2000 dilution + U-251 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • IHC-P - CTSD Antibody AM2221B
    AM2221b staining CTSD in human lung adenocarcinoma tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P07339
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone/Animal Names 892CT11.1.1
Calculated MW 44552 Da
Additional Information
Gene ID 1509
Other Names Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Target/Specificity Purified His-tagged CTSD protein was used to produced this monoclonal antibody.
Dilution WB~~1:2000
IHC-P~~1:25
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTSD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTSD
Synonyms CPSD
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Cellular Location Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)
Tissue Location Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Research Areas
Citations ( 0 )

Background

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

References

Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).
Faust P.L., et al. Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R., et al. Nucleic Acids Res. 15:3773-3786(1987).
Redecker B., et al. DNA Cell Biol. 10:423-431(1991).
Ebert L., et al. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 365.00
$ 140.00
Cat# AM2221B
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