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Creatine Kinase BB Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
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  • WB - Creatine Kinase BB Antibody  (Center) AM2198b
    Creatine Kinase BB (CKB) Antibody (Center) (Cat. #AM2198b) western blot analysis in MDA-MB453,293,Y79 cell line ,mouse stomach and brain tissue lysates (35μg/lane).This demonstrates the CKB antibody detected the CKB protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P12277
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone/Animal Names 893CT29.1.1
Calculated MW 42644 Da
Additional Information
Gene ID 1152
Other Names Creatine kinase B-type, B-CK, Creatine kinase B chain, CKB, CKBB
Target/Specificity Purified His-tagged CKB protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCreatine Kinase BB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CKB (HGNC:1991)
Synonyms CKBB
Function Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N- phosphocreatine as heat without performing any mechanical or chemical work (By similarity).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region {ECO:0000250|UniProtKB:Q04447}
Research Areas
Citations (0)
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Background

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

References

Villarreal-Levy G., et al. Biochem. Biophys. Res. Commun. 144:1116-1127(1987).
Mariman E.C.M., et al. Genomics 1:126-137(1987).
Kaye F.J., et al. J. Clin. Invest. 79:1412-1420(1987).
Mariman E.C.M., et al. Nucleic Acids Res. 17:6385-6385(1989).
Ota T., et al. Nat. Genet. 36:40-45(2004).

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$ 365.00
$ 140.00
Cat# AM2198b
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