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ERCC1 Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P07992 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM,k |
| Clone/Animal Names | 752CT13.2.5 |
| Calculated MW | 32562 Da |
| Antigen Region | 268-297 aa |
| Gene ID | 2067 |
|---|---|
| Other Names | DNA excision repair protein ERCC-1, ERCC1 |
| Target/Specificity | This ERCC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the C-terminal region of human ERCC1. |
| Dilution | WB~~1:2000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ERCC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ERCC1 |
|---|---|
| Function | [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. |
| Cellular Location | [Isoform 1]: Nucleus [Isoform 3]: Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
References
van Duin M., et al. Cell 44:913-923(1986).
Hoeijmakers J.H.J., et al. Cold Spring Harb. Symp. Quant. Biol. 51:91-101(1986).
Yu J.J., et al. Mutat. Res. 382:13-20(1997).
Hisatomi H., et al. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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