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CD138 Antibody (C-term) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC, E |
|---|---|
| Primary Accession | P18827 |
| Other Accession | NP_001006947.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 587CT7.3.6.5 |
| Calculated MW | 32462 Da |
| Antigen Region | 210-238 aa |
| Gene ID | 6382 |
|---|---|
| Other Names | Syndecan-1, SYND1, CD138, SDC1, SDC |
| Target/Specificity | This CD138 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the C-terminal region of human CD138. |
| Dilution | IF~~1:10~50 WB~~1:500~8000 FC~~1:10~50 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD138 Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SDC1 (HGNC:10658) |
|---|---|
| Synonyms | SDC |
| Function | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Secreted Secreted, extracellular exosome Note=Shedding of the ectodomain produces a soluble form |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
References
Tsai, E.W., et al. Transplantation 90(8):875-881(2010) Hozumi, K., et al. FEBS Lett. 584(15):3381-3385(2010) Zyada, M.M., et al. Ann Diagn Pathol 14(3):153-161(2010) Al-Shibli, K., et al. APMIS 118(5):371-382(2010) Szumilo, J., et al. Folia Histochem. Cytobiol. 47(4):571-578(2009)
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