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GNAS Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5FWY2 |
| Other Accession | P29797, Q8R4A8, P63095, P63094, P63092, P04896, Q63803, Q6R0H7, Q5JWF2 |
| Reactivity | Mouse |
| Predicted | Human, Rat, Bovine, Hamster, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 559CT 16.1.3 |
| Calculated MW | 44250 Da |
| Antigen Region | 287-315 aa |
| Gene ID | 2778 |
|---|---|
| Other Names | GNAS complex locus;GNAS; |
| Target/Specificity | This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS. |
| Dilution | WB~~1:300 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNAS Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNAS {ECO:0000313|EMBL:AAH89157.2} |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). |
| Cellular Location | Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
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