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HNF1A Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P20823 |
| Other Accession | P15257, P22361, NP_000536.4 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 622CT11.9.6 |
| Calculated MW | 67386 Da |
| Antigen Region | 177-205 aa |
| Gene ID | 6927 |
|---|---|
| Other Names | Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, Transcription factor 1, TCF-1, HNF1A, TCF1 |
| Target/Specificity | This HNF1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 177-205 amino acids from human HNF1A . |
| Dilution | WB~~1:100~1600 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HNF1A Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HNF1A |
|---|---|
| Synonyms | TCF1 |
| Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:38018242} |
| Tissue Location | Liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Ley, S.H., et al. Cardiovasc Diabetol 9, 39 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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