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CAT Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P04040 |
| Other Accession | P04762, O62839, P24270, Q9PT92, P00432, NP_001743.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Zebrafish, Pig, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone/Animal Names | 626CT4.3.8 |
| Calculated MW | 59756 Da |
| Antigen Region | 152-180 aa |
| Gene ID | 847 |
|---|---|
| Other Names | Catalase, CAT |
| Target/Specificity | This CAT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CAT. |
| Dilution | WB~~1:1600 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAT Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAT |
|---|---|
| Function | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). |
| Cellular Location | Peroxisome matrix |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
References
Banerjee, M., et al. Toxicol. Appl. Pharmacol. 249(1):47-54(2010)
Wu, S.H., et al. Clin. Chim. Acta 411 (21-22), 1705-1710 (2010) :
Liu, L., et al. J. Invest. Dermatol. 130(11):2647-2653(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dutkiewicz, G., et al. Nephrology (Carlton) 15(5):587-591(2010)
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