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GSTM1 Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P09488 |
| Other Accession | NP_000552.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 524CT17.2.5 |
| Calculated MW | 25712 Da |
| Antigen Region | 184-211 aa |
| Gene ID | 2944 |
|---|---|
| Other Names | Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GSTM1, GST1 |
| Target/Specificity | This GSTM1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from human GSTM1. |
| Dilution | WB~~1:500~2000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSTM1 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSTM1 (HGNC:4632) |
|---|---|
| Synonyms | GST1 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
References
Palli, D., et al. Mutagenesis 25(6):569-575(2010)
Henderson, A.J., et al. Thorax 65(10):897-902(2010)
Filonzi, L., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):743-747(2010)
Smith, G., et al. Pharmacogenet. Genomics (2010) In press :
Wang, T., et al. J. Int. Med. Res. 38(3):977-986(2010)
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