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B2M Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61769 |
| Other Accession | NP_004039.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 467CT12.3.1 |
| Calculated MW | 13715 Da |
| Antigen Region | 10-39 aa |
| Gene ID | 567 |
|---|---|
| Other Names | Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M |
| Target/Specificity | This B2M antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from human B2M. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | B2M Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | B2M (HGNC:914) |
|---|---|
| Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). |
| Cellular Location | Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rennella, E., et al. J. Mol. Biol. 401(2):286-297(2010)
Debelouchina, G.T., et al. J. Am. Chem. Soc. 132(30):10414-10423(2010)
Mumtaz, A., et al. Saudi J Kidney Dis Transpl 21(4):701-706(2010)
Guo, H.C., et al. Nature 360(6402):364-366(1992)
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