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FUT4 Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P22083 |
| Other Accession | Q11127, NP_002024.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 476CT26.8.4 |
| Calculated MW | 59084 Da |
| Antigen Region | 425-454 aa |
| Gene ID | 2526 |
|---|---|
| Other Names | Alpha-(1, 3)-fucosyltransferase 4, 241-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A |
| Target/Specificity | This FUT4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from human FUT4. |
| Dilution | WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUT4 {ECO:0000303|PubMed:29593094} |
|---|---|
| Function | [Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:1702034, PubMed:1716630, PubMed:29593094). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6- sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:1716630, PubMed:29593094). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:11278338, PubMed:1716630). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi |
| Tissue Location | [Isoform Short]: Expressed at low levels in bone marrow-derived mesenchymal stem cells. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).
References
Yang, X.S., et al. J. Cell. Physiol. 225(2):612-619(2010)
Trubiani, O., et al. J. Cell. Physiol. 225(1):123-131(2010)
Pruszak, J., et al. Stem Cells 27(12):2928-2940(2009)
Ogata, K., et al. Haematologica 94(8):1066-1074(2009)
Read, T.A., et al. Cancer Cell 15(2):135-147(2009)
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$ 192.50
$ 75.00
Cat# AM2040a
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