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Myoglobin Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P02144 |
| Other Accession | P02189, P02150, NP_005359.1, P68082 |
| Reactivity | Human, Mouse |
| Predicted | Horse, Monkey, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 444CT19.2.1 |
| Calculated MW | 17184 Da |
| Antigen Region | 103-130 aa |
| Gene ID | 4151 |
|---|---|
| Other Names | Myoglobin, MB |
| Target/Specificity | This Myoglobin antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from human Myoglobin. |
| Dilution | WB~~1:1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Myoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MB (HGNC:6915) |
|---|---|
| Function | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). |
| Cellular Location | Cytoplasm, sarcoplasm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.
References
Esquerra, R.M., et al. Phys Chem Chem Phys 12(35):10270-10278(2010)
Endeward, V., et al. Cardiovasc. Res. 87(1):22-29(2010)
Balobanov, V.A., et al. Mol. Biol. (Mosk.) 44(4):708-717(2010)
Kristiansen, G., et al. Br. J. Cancer 102(12):1736-1745(2010)
Rayner, B.S., et al. Biochem. J. 423(2):169-177(2009)
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