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TLE4 Antibody (Center)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q04727 |
| Other Accession | Q07141, Q62441, NP_008936.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 384CT24.1.3.4 |
| Calculated MW | 83755 Da |
| Antigen Region | 262-290 aa |
| Gene ID | 7091 |
|---|---|
| Other Names | Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261 |
| Target/Specificity | This TLE4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human TLE4. |
| Dilution | WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TLE4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLE4 |
|---|---|
| Synonyms | GRG4, KIAA1261 |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | In all tissues examined, mostly in brain, and muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
References
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :
Stolk, L., et al. Nat. Genet. (2009) In press :
Dayyani, F., et al. Blood 111(8):4338-4347(2008)
Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
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