Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
GJC2 Antibody (N-term)(Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5T442 |
| Other Accession | Q80XF7, Q8BQU6, Q29RK8, Q7ZXS7, A4GG66, A4GVD1, P28229, P36383, Q92052, Q6R4A8, P18861, Q2HJ66, NP_065168.2 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Hamster, Zebrafish, Mouse, Pig, Rat, Xenopus |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 391CT6.4.3 |
| Calculated MW | 47002 Da |
| Antigen Region | 53-78 aa |
| Gene ID | 57165 |
|---|---|
| Other Names | Gap junction gamma-2 protein, Connexin-466, Cx466, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12 |
| Target/Specificity | This GJC2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 53-78 amino acids from the N-terminal region of human GJC2. |
| Dilution | WB~~1:100~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GJC2 Antibody (N-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJC2 |
|---|---|
| Synonyms | GJA12 |
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
| Tissue Location | Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
References
Ferrell, R.E., et al. Am. J. Hum. Genet. 86(6):943-948(2010)
Wang, J., et al. Brain Dev. 32(3):236-243(2010)
Ishikawa, T., et al. Rinsho Shinkeigaku 50(1):7-11(2010)
Ruf, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2), 226-232 (2009) :
Orthmann-Murphy, J.L., et al. Brain 132 (PT 2), 426-438 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
