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NUAK2 Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H093 |
| Other Accession | NP_112214.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 378CT15.4.5 |
| Calculated MW | 69612 Da |
| Gene ID | 81788 |
|---|---|
| Other Names | NUAK family SNF1-like kinase 2, Omphalocele kinase 2, SNF1/AMP kinase-related kinase, SNARK, NUAK2 {ECO:0000312|EMBL:AAH173061}, OMPHK2, SNARK |
| Target/Specificity | Purified His-tagged NUAK2 protein(Fragment) was used to produced this monoclonal antibody. |
| Dilution | WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NUAK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUAK2 {ECO:0000312|EMBL:AAH17306.1} |
|---|---|
| Synonyms | OMPHK2, SNARK |
| Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells.
References
Koh, H.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15541-15546(2010)
Rune, A., et al. Diabetologia 52(10):2182-2189(2009)
Kuga, W., et al. Biochem. Biophys. Res. Commun. 377(4):1062-1066(2008)
Kim, J.H., et al. Leuk. Lymphoma 49(7):1392-1398(2008)
Yamamoto, H., et al. Biochem. Biophys. Res. Commun. 365(3):541-547(2008)
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