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INS Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P01308 |
| Other Accession | NP_001172027.1, NP_001172026.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 396CT20.4.4 |
| Calculated MW | 11981 Da |
| Antigen Region | 35-64 aa |
| Gene ID | 3630 |
|---|---|
| Other Names | Insulin, Insulin B chain, Insulin A chain, INS |
| Target/Specificity | This INS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from human INS. |
| Dilution | WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INS Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INS |
|---|---|
| Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
References
Hinks, A., et al. Ann. Rheum. Dis. 69(12):2169-2172(2010)
Breuer, T.G., et al. Eur. J. Endocrinol. 163(4):551-558(2010)
Andersen, M.K., et al. Diabetes Care 33(9):2062-2064(2010)
Ferron, M., et al. Cell 142(2):296-308(2010)
Authier, F., et al. J. Biol. Chem. 277(11):9437-9446(2002)
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