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THAP11 Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EK4 |
| Other Accession | A5PKF5, NP_065190.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 364CT25.4.2 |
| Calculated MW | 34455 Da |
| Antigen Region | 165-193 aa |
| Gene ID | 57215 |
|---|---|
| Other Names | THAP domain-containing protein 11, THAP11 |
| Target/Specificity | This THAP11 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human THAP11. |
| Dilution | WB~~1:8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | THAP11 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THAP11 |
|---|---|
| Function | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
References
Zhu, C.Y., et al. Cell Death Differ. 16(3):395-405(2009)
Dejosez, M., et al. Cell 133(7):1162-1174(2008)
Roussigne, M., et al. Trends Biochem. Sci. 28(2):66-69(2003)
Ueki, N., et al. Nat. Biotechnol. 16(13):1338-1342(1998)
Li, S.H., et al. Genomics 16(3):572-579(1993)
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