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IHH Antibody (C-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - IHH Antibody (C-term) (Ascites) AM1981a
    IHH antibody (C-term) (Cat. #AM1981a) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14623
Other Accession O75473, F1MT22, NP_034674.1
Reactivity Human
Predicted Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone/Animal Names 363CT4.1.6
Calculated MW 45251 Da
Additional Information
Gene ID 3549
Other Names Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH
Target/Specificity This IHH Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human IHH.
Dilution WB~~1:500~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIHH Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IHH (HGNC:5956)
Function [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling (PubMed:24342078). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (PubMed:20839884).
Cellular Location [Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}
Tissue Location Expressed in embryonic lung, and in adult kidney and liver
Research Areas
Citations (0)
citation

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Background

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

References

van Dop, W.A., et al. Gastroenterology 139(5):1665-1676(2010) Koike, S., et al. Biochem. Biophys. Res. Commun. 400(1):66-71(2010) Rice, D.P., et al. Hum. Mol. Genet. 19(17):3457-3467(2010) Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010) Lyashenko, N., et al. Dev. Dyn. 239(8):2266-2277(2010)

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$ 182.50
Cat# AM1981a
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