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IHH Antibody (C-term) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14623 |
| Other Accession | O75473, F1MT22, NP_034674.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 |
| Clone/Animal Names | 363CT4.1.6 |
| Calculated MW | 45251 Da |
| Gene ID | 3549 |
|---|---|
| Other Names | Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH |
| Target/Specificity | This IHH Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human IHH. |
| Dilution | WB~~1:500~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IHH Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IHH (HGNC:5956) |
|---|---|
| Function | [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C- terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling (PubMed:24342078). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (PubMed:20839884). |
| Cellular Location | [Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465} |
| Tissue Location | Expressed in embryonic lung, and in adult kidney and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
References
van Dop, W.A., et al. Gastroenterology 139(5):1665-1676(2010) Koike, S., et al. Biochem. Biophys. Res. Commun. 400(1):66-71(2010) Rice, D.P., et al. Hum. Mol. Genet. 19(17):3457-3467(2010) Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010) Lyashenko, N., et al. Dev. Dyn. 239(8):2266-2277(2010)
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